Mechanical resonators are highly versatile tools for hybrid quantum technologies due to their many available bosonic modes with long coherence times. In order to unlock applications such as quantum simulation and sensing, however, it is necessary to develop tools for the preparation and detection of mechanical quantum states. In this talk, I will report our results on realizing scalable and programmable approaches to prepare and characterize a variety of non-classical states of motion in the resonator. These techniques will find applications in the simulation of many-body Hamiltonians and in quantum metrology. Moreover, due to its microgram-scale mass, our systems have the potential to explore the interplay between quantum mechanics and gravity.