报告摘要 |
The fabrication of nanophotonic elements out of soft materials provides new frontiers for the integration of photonics with biosystems, and provides ways to realize microscopic devices that could not be made otherwise. Here we present one example: a nanoparticle and virus imaging platform enabled by nano-scale lenses that are self-assembled out of polyethylene glycol. Currently, nanoparticle sizing and imaging are typically performed using sophisticated laboratory-based electron microscopes or optical systems, even though such analyses can be time-intensive, costly, and/or not readily available in areas such as developing or rural regions. Rapid and inexpensive nanoparticle imaging and sizing is important in medical, environmental, and basic research, and could enable, for example, point-of-care quantification of viral load in HIV patients, multiplexed biochemical assays, or widespread air quality and water quality environmental monitoring. Here we perform accurate nanoparticle imaging and sizing using the combination of nanolenses and on-chip, in-line holography. This combined approach simultaneously provides high resolution, large field of view, and a cost-effective and field-portable hardware system. We can size particles of diameter 40 nm – 100 um, where the accuracy is +/- 11 nm for the 40 nm – 500 nm range. Our approach can size more than 10^5 particles simultaneously, can detect particles of various shapes, and can recover multi-modal distributions of sizes, all within a compact and inexpensive prototype device.
报告人简介：Euan McLeod has been an assistant professor at the College of Optical Sciences in the University of Arizona since 2015. He was previously a postdoc in Electrical Engineering and Bioengineering at UCLA, as well as a postdoc in Applied Physics at Caltech. He received his Ph.D. from Princeton University in 2009, and his B.S. from Caltech in 2004. Euan’s background and interests lie at the intersection of optics, nanoscience, and soft bio-materials science. He has published more than 20 papers on these topics in peer-reviewed journals, with major contributions in the areas of high-speed varifocal lenses based on acoustic modulation, optical trap-assisted nanopatterning, and lensfree holographic imaging of nanoparticles and viruses.
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