报告摘要 |
Optical microscopy has been a fundamental tool to life science and materials science since its invention in the 17th century. Various labeling approaches have enabled selective visualization of cellular structures or biomolecules with high specificity under a light microscope. Despite great advances made recently, the labeling approach also has limitations: First, labels may perturb the function of a biological molecule or structure; Second, the labeling approach offers limited capacity of discovery because it is only applicable to mapping known species; Third, delivery of labels to a target could be difficult, especially under in vivo conditions; Fourth, potential toxicity often prevents the use of labels on human patients. Chemical microscopy, based on optical spectroscopic signals, open a way to circumvent these barriers. I will present how various advanced modalities of chemical microscopy are developed and how these technical innovations enabled discoveries of hidden signatures in microstructures.
报告人简介：Ji-Xin Cheng attended University of Science and Technology of China (USTC) from 1989 to 1994. From 1994 to 1998, he carried out his PhD study on bond-selective chemistry under the supervision of Qingshi Zhu at USTC. As a graduate student, he worked as a research assistant at Universite Paris-sud (France) on vibrational spectroscopy and the Hong Kong University of Science and Technology (HKUST) on quantum dynamics theory. After postdoctoral training on ultrafast spectroscopy in Yijing Yan’s group at HKUST, he joined Sunney Xie’s group at Harvard University as a postdoc, where he and others developed CARS microscopy that allows high-speed vibrational imaging of cells and tissues. Cheng joined Purdue University in 2003 as Assistant Professor in Weldon School of Biomedical Engineering and Department of Chemistry, promoted to Associate Professor in 2009 and Full Professor in 2013. He joined Boston University as the Moustakas Chair Professor in Photonics and Optoelectronics in summer 2017. Professor Cheng and his research team has been constantly at the most forefront of the rising field of label-free chemical imaging in technical innovation, science, commercialization, and clinical translation.
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